MPI instrumentation comprises the analysis and development of all components necessary for clinical and preclinical imaging along the transmission and reception chain of this imaging modality as well as the development of devices for testing and characterizing nanoparticles, including the identification and consideration of potentials for clinical applications and therapies. Instrumentation is a crucial part of the research to realize the full potential of MPI. This includes the development of dedicated filter circuits and special field topologies to achieve spatial coding and particle excitation. The recording of the weak particle signals with high quality is achieved by the development of amplifiers specially tuned to the receiving characteristics of the respective system.
Research at Fraunhofer IMTE is particularly focused on the combination of electromagnets and permanent magnets for the generation of the required fields. Using a smart arrangement of permanent magnets in a so-called Halbach configuration, strong magnetic fields can be realized without the need for electrical power for field generation. This leads to compact systems which have high potential for a number of applications, especially in preclinical research. Our current scanner concept offers an ideal basis for preclinical research with functionalized magnetic nanoparticles and, to the same extent, for the further development of instrumentation and dedicated reconstruction algorithms.