I.N.V.I. Sense^base product family

The I.N.V.I. Sense product family represents a paradigm shift in magnetic nanoparticle (MNP) research and synthesis monitoring. Conventional magnetic particle spectrometry (MPS) is limited to post-synthesis characterization of microliter-scale samples, leaving nucleation and growth mechanisms largely unobserved.

To address this limitation, I.N.V.I. Sense enables real time, in situ monitoring without expensive ancillary equipment or specialized expertise. It comprises two complementary solutions: I.N.V.I. Sense^base for batch synthesis and I.N.V.I. Sense^{base cf} for continuous-flow operations.

Your Benefits

I.N.V.I. Sense^base: Autonomous Batch Synthesis Monitoring

The standard I.N.V.I. Sense^base is a tabletop instrument designed for real time characterization of MNPs during laboratory scale synthesis. Unlike transmission electron microscopy (TEM) or X ray spectroscopy, both of which are costly, require specific expertise and depend on specialized measurement chambers, I.N.V.I. Sense^base operates within conventional laboratory flasks with volumes of 25 to 50 ml installed in a standard fume hood.

The device integrates a fully controllable heating unit, enabling autonomous coprecipitation synthesis with measurement acquisition within a few milliseconds, depending on synthesis kinetics. Once initiated, the system operates independently and requires minimal user intervention.

Real time magnetic signature monitoring provides insight into particle nucleation and growth without sample extraction. It generates continuous datasets that would otherwise require multiple TEM or spectroscopy sessions after synthesis. Low power consumption and a compact form factor facilitate seamless integration into existing chemical workflows.

I.N.V.I. Sense^{base cf}: Continuous-flow Synthesis and Rapid Optimization

Building on the core strengths of I.N.V.I. Sense^base, I.N.V.I. Sense^{base cf} extends the product family to high throughput continuous-flow synthesis and real time parameter optimization. 

I.N.V.I. Sense^{base cf} features five programmable channels for raw material delivery (flow rates 5 - 8,000 μl/min at 500 mbar) combined with dual heating/cooling environments (1 - 80 °C), enabling rapid exploration of synthesis parameter space. Critically, the integrated five-channel MPS system permits real-time quality assessment at multiple synthesis timepoints with user-defined field strengths at 25 kHz sinusoidal excitation.

This architecture supports both small-scale R&D and moderate manufacturing throughput, dramatically reducing experimental cycle time by eliminating the need to complete full syntheses before evaluating intermediate states.

The system's software interface centralizes control of temperature, flow rates, and dosing, minimizing human error and enabling AI-driven synthesis analysis and predictive modeling for accelerated optimization.

Technical Highlights of the I.N.V.I. Sense^base & I.N.V.I. Sense^{base cf}

• Research and development of magnetic nanostructures
• Real-time monitoring of particle formation and growth mechanisms
• Optimization of synthesis parameters and process conditions
• Comparison of different synthesis approaches and material formulations
• Continuous-flow synthesis and process development
• Quality control during nanoparticle production
• Preparation of scale-up processes from lab-scale research to application-oriented workflows
• Development of more reproducible and efficient laboratory processes

Services and Collaboration

We support researchers and industrial partners in applying I.N.V.I. Sense^base and I.N.V.I. Sense^{base cf} technologies to specific questions in magnetic nanoparticle synthesis and characterization. Depending on the application, this may include feasibility studies, measurement campaigns, method development, process optimization or workflow adaptation.

• Application-oriented consulting: We assess how real-time, in-situ magnetic particle characterization can support your research or development process.
• Feasibility studies and measurements: We provide experimental support to evaluate synthesis processes, compare parameters and generate meaningful magnetic particle data.
• Method and process development: We develop and optimize workflows for batch synthesis, continuous-flow applications and scale-up preparation.
• Collaborative R&D projects: We support joint research and development projects from early-stage ideas to application-oriented solutions.

For application-specific requirements beyond the I.N.V.I. Sensebase systems, Fraunhofer IMTE also develops customized Magnetic Particle Spectrometers for individual research and development needs.